5-Bromo-1H-pyrrole-3-carbaldehyde(CAS: 881676-32-0)

5-Bromo-1H-pyrrole-3-carbaldehyde is a crystalline compound with a molecular weight of approximately 192.03 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is known for its reactivity, particularly in nucleophilic substitution and condensation reactions. It features a broad absorption in the UV-Vis range, indicating its chromophoric nature.

5-Bromo-1H-pyrrole-3-carbaldehyde is commonly synthesized through bromination of 1H-pyrrole-3-carbaldehyde. This involves the addition of bromine to the pyrrole ring under alkaline conditions. Commonly used catalysts include sodium hydride, and the reaction typically provides a yield of around 70-80%. The exact conditions can vary depending on the specific methodology.

5-Bromo-1H-pyrrole-3-carbaldehyde is used in various industries, particularly in the pharmaceutical sector for the synthesis of drugs and intermediates. It is also used in the production of organic polymers and in the development of sensors and materials. Its properties make it suitable for applications requiring reactive functional groups and specific chromophoric characteristics.

When handling 5-Bromo-1H-pyrrole-3-carbaldehyde, it is crucial to use personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or a fume hood to minimize exposure to bromine vapors. Spills should be handled with appropriate absorbents, and proper safety data sheets (SDS) should be consulted for detailed emergency procedures.