1-(3-Chloro-2-pyridinyl)ethanone(CAS: 131109-75-6)

1-(3-Chloro-2-pyridinyl)ethanone is a crystalline solid with a molecular weight of 169.59 g/mol. It has a solubility of approximately 1.4 g/100 mL in water and is slightly soluble in common organic solvents. Chemically, it is moderately reactive, showing some electrophilic aromatic substitution potential. Its purity can be confirmed using analytical techniques such as NMR and LC-MS.

1-(3-Chloro-2-pyridinyl)ethanone is commonly synthesized through electrophilic aromatic substitution of 2-chloro-3-pyridinecarbaldehyde. The reaction typically involves the use of a Lewis acid catalyst like aluminum chloride, with yields ranging from 60% to 80%. The product is isolated through recrystallization or distillation.

1-(3-Chloro-2-pyridinyl)ethanone finds applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of drugs. It is also utilized in the development of certain sensors and in the production of specialized polymers. Its use in semiconductors is limited but may be explored in niche applications.

When handling 1-(3-Chloro-2-pyridinyl)ethanone, ensure proper ventilation and use a fume hood. Wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Avoid skin contact and inhalation. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.