4-Chloro-6-methoxy-2-methylpyrimidine(CAS: 89466-39-7)

4-Chloro-6-methoxy-2-methylpyrimidine is a white crystalline solid with a molecular weight of approximately 211.6 g/mol. It is slightly soluble in water but highly soluble in organic solvents such as methanol and ethanol. Chemically, it is stable under normal conditions but reactive towards nucleophiles. It has a melting point of around 160-162°C and decomposes above 190°C. The compound is known for its moderate basicity and can participate in various synthetic reactions.

4-Chloro-6-methoxy-2-methylpyrimidine is typically synthesized through the reaction of 2-methylpyrimidine with chlorosulfonic acid, followed by methylation using methyl iodide. The process involves the generation of a chlorosulfonated intermediate, which is then methylated to yield the final product. The yield is around 90%, and the reaction is catalyzed by a suitable acid to enhance the regioselectivity.

4-Chloro-6-methoxy-2-methylpyrimidine is used in various industries, particularly in the pharmaceutical sector for the synthesis of drugs. It is also utilized in the chemical industry for intermediates in polymer synthesis and in the production of sensors and semiconductors. Its unique chemical structure makes it valuable in these applications.

When handling 4-Chloro-6-methoxy-2-methylpyrimidine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and protective clothing. It should be handled in a well-ventilated area or a fume hood. In case of a spill, immediately clean up with caution, ensuring to avoid skin or eye contact. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.