2-Bromo-4-fluorobenzaldehyde(CAS: 59142-68-6)

2-Bromo-4-fluorobenzaldehyde (CAS: 59142-68-6) is a crystalline solid with a molecular weight of approximately 217.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly with nucleophiles and reducing agents. It reacts with amines to form N-substituted derivatives and can be reduced to 2-bromo-4-fluorobenzyl alcohol.

2-Bromo-4-fluorobenzaldehyde (CAS: 59142-68-6) is commonly synthesized via bromination of 4-fluorobenzaldehyde using N-bromosuccinimide (NBS) in the presence of a radical initiator like AIBN. The reaction involves electrophilic aromatic substitution, followed by reduction of the bromo group to form the aldehyde. The yield is around 70-80%, and the process is conducted under mild conditions to ensure high selectivity.

2-Bromo-4-fluorobenzaldehyde (CAS: 59142-68-6) is utilized in the pharmaceutical industry for the synthesis of various intermediates and active pharmaceutical ingredients. It also finds applications in the production of polymers, where it serves as a monomer or a coupling agent. Additionally, it is used in the development of sensors and semiconductors, particularly in the preparation of functionalized materials.

Handling 2-Bromo-4-fluorobenzaldehyde (CAS: 59142-68-6) requires appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. In case of spill, immediately clean up using appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.