Diethyl allylmalonate(CAS: 2049-80-1)

Diethyl allylmalonate (CAS: 2049-80-1) is a colorless liquid with a molecular weight of approximately 194.24 g/mol. It has a pKa of around 4.5 and is soluble in organic solvents like ethanol and acetone but less so in water. Its reactivity is moderate and it can undergo esterification and nucleophilic substitution reactions.

Diethyl allylmalonate (CAS: 2049-80-1) is typically synthesized via the reaction of allylmalonate with diethyl magnesium followed by hydrolysis. Commonly, the Grignard reagent is used as a catalyst, providing good selectivity and yield. The reaction is carried out under anhydrous conditions to prevent side reactions.

Diethyl allylmalonate (CAS: 2049-80-1) finds applications in the pharmaceutical industry as a precursor for the synthesis of certain drugs. It is also used in the polymer industry as a plasticizer, and in the chemical industry for the production of monomers and other organic compounds. Additionally, it has potential uses in the sensor and semiconductor industries.

When handling Diethyl allylmalonate (CAS: 2049-80-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. Fume hoods should be used during handling to prevent inhalation. In case of a spill, it should be handled according to the Material Safety Data Sheet (MSDS).