2-(Trifluoromethyl)acrylic acid(CAS: 381-98-6)

2-(Trifluoromethyl)acrylic acid (CAS: 381-98-6) is a colorless or white crystalline solid with a molecular weight of approximately 159.05 g/mol. It has a pKa of 4.2 and is slightly soluble in water. It reacts readily with bases and nucleophiles. This compound is also known for its high boiling point and low vapor pressure.

2-(Trifluoromethyl)acrylic acid is typically synthesized via the reaction of trifluoromethyl acetyl chloride with sodium methoxide. This process yields a 90% yield of the desired product with high structural integrity. The reaction is conducted under mild conditions to ensure selectivity and purity.

2-(Trifluoromethyl)acrylic acid (CAS: 381-98-6) is widely used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and in the polymer industry for the production of functional polymers. It is also utilized in the development of sensors and semiconductors due to its unique chemical properties.

When handling 2-(Trifluoromethyl)acrylic acid (CAS: 381-98-6), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store the compound in a cool, well-ventilated area away from heat and open flames. Use a fume hood when preparing or using the compound to avoid inhalation. In case of spillage, follow the safety data sheet (SDS) guidelines for cleanup and disposal.