2,6-Difluoro-3-nitrobenzoic acid(CAS: 83141-10-0)

2,6-Difluoro-3-nitrobenzoic acid is a crystalline solid with a molecular weight of approximately 217.05 g/mol. It has a low solubility in water (0.2 g/L at 25°C) but is more soluble in organic solvents like methanol and ethanol. The compound is known for its high reactivity, particularly with reducing agents, and shows moderate acidity due to the carboxylic acid group.

2,6-Difluoro-3-nitrobenzoic acid is commonly synthesized by the nitration of 2,6-difluorobenzoic acid. This involves reacting the starting material with a mixture of nitric and sulfuric acids. The process yields a mixture that requires recrystallization to obtain pure 2,6-difluoro-3-nitrobenzoic acid, with good selectivity and a yield typically around 70-80%.

2,6-Difluoro-3-nitrobenzoic acid finds applications in the pharmaceutical industry for the synthesis of certain drugs due to its functional groups. It is also used in the polymer industry as a precursor for the synthesis of various polymers. Additionally, it is employed in the production of sensors and semiconductors for its specific reactivity and functionality.

When handling 2,6-Difluoro-3-nitrobenzoic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and chemical-resistant lab coats. Work should be carried out in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials, following proper disposal procedures as outlined in the Safety Data Sheet (SDS).