1,4-dimethyl-1H-pyrazole-5-carboxylic acid(CAS: 13745-58-9)

1,4-Dimethyl-1H-pyrazole-5-carboxylic acid is a solid with a crystalline form. Its molecular weight is approximately 186.22 g/mol. It has a slight solubility in water and is more soluble in organic solvents. It is reactive towards basic conditions and can undergo condensation reactions, making it useful in chemical synthesis.

1,4-Dimethyl-1H-pyrazole-5-carboxylic acid can be synthesized through the condensation of 4-formyl-1,4-dimethylpyrazole with acetic anhydride. The reaction is typically catalyzed by an acid, such as sulfuric acid, and proceeds under mild heating. The yield is generally around 70-80%, and the product is purified by crystallization.

1,4-Dimethyl-1H-pyrazole-5-carboxylic acid is used in the pharmaceutical and chemical industries. It serves as a precursor for the synthesis of various drugs and also finds applications in the production of polymers and sensors. Its use in semiconductors and other advanced materials is also being explored.

When handling 1,4-dimethyl-1H-pyrazole-5-carboxylic acid, use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from heat and ignition sources. In case of spill, use gloves and a fume hood to clean up. Refer to the Safety Data Sheet (SDS) for more detailed information on handling and safety measures.