1,3-Dihydro-2H-imidazo[4,5-c]pyridin-2-one(CAS: 7397-68-4)

1,3-Dihydro-2H-imidazo[4,5-c]pyridin-2-one is a white to off-white crystalline solid with a molecular weight of approximately 146.12 g/mol. It is slightly soluble in water but soluble in organic solvents such as ethanol and acetone. Chemically, it is stable under normal conditions, but it can react with strong bases and acids. It has a pKa of about 5.5 and exhibits basic properties.

1,3-Dihydro-2H-imidazo[4,5-c]pyridin-2-one is commonly synthesized via the condensation of 2-amino-4,5-dihydroimidazole with acetylacetone. The reaction is typically carried out in the presence of a base such as sodium hydroxide or potassium hydroxide, yielding the product with good selectivity and moderate to high yields. Post-synthesis, it can be purified using column chromatography.

1,3-Dihydro-2H-imidazo[4,5-c]pyridin-2-one is used in pharmaceuticals for its potential as a precursor in the synthesis of drug candidates. It also finds applications in the polymer industry as a stabilizer and in sensor technology for its ability to act as a pH indicator. Additionally, it is used in the semiconductor industry as a dopant.

When handling 1,3-Dihydro-2H-imidazo[4,5-c]pyridin-2-one, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from strong acids and bases. In case of a spill, it should be cleaned up using absorbent material and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.