(2E)-3-(2-Hydroxyphenyl)acrylic acid(CAS: 614-60-8)

(2E)-3-(2-Hydroxyphenyl)acrylic acid is a white crystalline solid with a molecular weight of approximately 154.17 g/mol. It has a pKa of about 3.5 and is slightly soluble in water. This compound is reactive and can undergo various polymerization and condensation reactions.

(2E)-3-(2-Hydroxyphenyl)acrylic acid can be synthesized via the hydroxylation of 3-bromopropenal followed by amination. Common methods include using hydrogen peroxide and a catalyst like iron(III) chloride. The yield is around 70-80%, and the selectivity is high for the desired product.

(2E)-3-(2-Hydroxyphenyl)acrylic acid is used in pharmaceuticals for its antioxidant properties, in polymers for its stabilizing effects, and in sensors for its reactivity. It also finds applications in the development of organic semiconductors.

When handling (2E)-3-(2-Hydroxyphenyl)acrylic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a dry, cool place away from heat sources. Handle under a fume hood to avoid inhalation of fumes. In case of spill, neutralize with a base, then clean up with absorbent material. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.