2-{[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfanyl}-1H-benzimidazole(CAS: 103312-62-5)

2-{[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfanyl}-1H-benzimidazole is a crystalline compound with a molecular weight of approximately 313.02 g/mol. It has limited solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound is known to be chemically stable under normal conditions but exhibits acidity and can undergo substitution reactions under certain conditions.

2-{[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfanyl}-1H-benzimidazole is typically synthesized via a Grignard reaction followed by a sulfide addition. The synthesis involves the reaction of 4-chloro-3-methyl-2-pyridine with a Grignard reagent, followed by the addition of a benzimidazole derivative. The process requires precise control of reaction conditions to achieve high yield and selectivity.

2-{[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfanyl}-1H-benzimidazole is primarily used in the pharmaceutical industry due to its potential as an antitumor agent. It is also explored for its applications in sensors and semiconductors, although its use in these areas is less common compared to pharmaceuticals.

Handling 2-{[(4-Chloro-3-methyl-2-pyridinyl)methyl]sulfanyl}-1H-benzimidazole should be done in a well-ventilated area, preferably in a fume hood. Protective equipment such as gloves, goggles, and a lab coat should be worn. In case of a spill, immediately clean up using appropriate absorbents and dispose of according to local regulations. Always consult the safety data sheet (SDS) for detailed information on handling and storage.