1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-proline(CAS: 37784-17-1)

1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-proline is a crystalline compound with a molecular weight of approximately 214.31 g/mol. It is sparingly soluble in water but readily soluble in organic solvents like methanol and ethanol. This compound is known for its reactivity, particularly in esterification reactions and amide formation. It has a melting point around 165-168°C and a pKa value in the range of 4.5-5.0.

1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-proline can be synthesized through a multi-step process involving the protection of the D-proline amine with a 2-methyl-2-propanol derivative. The key steps include the formation of an ester linkage followed by removal of the protecting group. Commonly used catalysts include HATU (O--Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate) and DIPEA (N,N-Diisopropylethylamine). The overall yield is typically around 60-70%.

1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-proline is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the polymer industry for the development of advanced materials. Additionally, it has potential applications in the sensor technology and semiconductor sectors due to its unique chemical properties.

When handling 1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-proline, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a dry, cool, and well-ventilated area, away from direct sunlight and heat sources. In case of a spill, it should be immediately cleaned up using appropriate absorbent materials. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS).