2-Chloro-1-(1-chlorocyclopropyl)ethanone(CAS: 120983-72-4)

2-Chloro-1-(1-chlorocyclopropyl)ethanone is a crystalline compound with a molecular weight of approximately 166.02 g/mol. It is slightly soluble in water and has a pKa of around 4.5. This compound is highly reactive due to the presence of electron-withdrawing chlorines, making it susceptible to nucleophilic substitution reactions. It has a melting point of about 55-57°C and a boiling point of around 125-127°C. It is not flammable but can decompose under certain conditions, releasing toxic gases.

2-Chloro-1-(1-chlorocyclopropyl)ethanone can be synthesized via several methods. One common route involves the alkylation of chlorocyclopropane with chloroacetyl chloride in the presence of a base like potassium tert-butoxide. Another method involves the chlorination of 1-(1-chlorocyclopropyl)ethanone. The yield is typically around 70-80%, and the selectivity for the desired product can be enhanced by careful control of reaction conditions.

2-Chloro-1-(1-chlorocyclopropyl)ethanone is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in polymer chemistry for producing certain types of plastics and in the development of sensors and electronic components. Its unique chemical properties make it valuable in these sectors for its reactivity and specific functional groups.

When handling 2-Chloro-1-(1-chlorocyclopropyl)ethanone, it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a fume hood to minimize exposure to its vapors. Spills should be cleaned up immediately with appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal. This compound should be stored in a cool, dry place away from direct sunlight and heat sources.