3,5-Dimethyl-1-phenyl-1H-pyrazole(CAS: 1131-16-4)

3,5-Dimethyl-1-phenyl-1H-pyrazole (CAS: 1131-16-4) is a crystalline solid with a molecular weight of approximately 158.23 g/mol. It has a low solubility in water (0.05 g/100 mL at 25°C) and is more soluble in organic solvents like methanol and chloroform. The compound is relatively stable under normal conditions but can react with strong acids and bases. It exhibits good thermal stability, with a melting point around 135°C.

3,5-Dimethyl-1-phenyl-1H-pyrazole can be synthesized through a multi-step reaction involving a coupling step and an imidization step. Commonly, this involves reacting 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylic acid or 3,5-dimethyl-1-phenyl-1H-pyrazole-4-amine with an appropriate coupling agent and base. The yield is typically around 70-80%, and the reaction is known for its good selectivity.

3,5-Dimethyl-1-phenyl-1H-pyrazole (CAS: 1131-16-4) finds applications in the pharmaceutical industry, where it serves as a precursor for developing new drugs. It is also used in the polymer industry for improving the properties of certain polymers. Additionally, it is utilized in the sensor industry for its ability to detect specific gases and in the semiconductor industry as a dopant.

When handling 3,5-Dimethyl-1-phenyl-1H-pyrazole (CAS: 1131-16-4), it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Always work in a well-ventilated area or a fume hood. Ensure proper storage in a cool, dry place away from direct sunlight. In case of spillage, immediately clean up using the appropriate materials and procedures. It is advisable to consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.