2,5,6-Trichloronicotinic acid(CAS: 54718-39-7)

2,5,6-Trichloronicotinic acid (CAS: 54718-39-7) is a crystalline solid with a molecular weight of 222.03 g/mol. It has a solubility of 12.5 g/L in water at 25°C. Chemically, it is highly reactive, particularly towards nucleophilic substitution reactions. It is slightly soluble in ethanol and insoluble in benzene.

2,5,6-Trichloronicotinic acid is typically synthesized by the chlorination of nicotinic acid using thionyl chloride as the chlorinating agent. The reaction is carried out in a solvent like dimethylformamide (DMF) under reflux conditions, yielding the target compound with high selectivity and good yield.

2,5,6-Trichloronicotinic acid finds applications in the pharmaceutical industry for the synthesis of certain drug intermediates. It is also used in the polymer industry for the production of special polymers, in sensor technology for the development of specific chemical sensors, and in the semiconductor industry for various analytical purposes.

When handling 2,5,6-Trichloronicotinic acid (CAS: 54718-39-7), wear appropriate personal protective equipment (PPE), including gloves, goggles, and a respirator. Work in a well-ventilated area or fume hood. Store in a cool, dry place, away from incompatible materials. In case of spill, use appropriate spill containment materials and follow SDS guidelines for disposal.