6-Methyl-1,3-benzodioxol-5-amine(CAS: 62052-49-7)

6-Methyl-1,3-benzodioxol-5-amine is a white crystalline solid with a molecular weight of approximately 204.23 g/mol. It is slightly soluble in water and has a pKa of around 8.5. The compound is reactive towards bases and can undergo substitution reactions, particularly with nucleophiles.

6-Methyl-1,3-benzodioxol-5-amine can be synthesized via the amide coupling of 6-methyl-1,3-benzodioxol-5-carboxylic acid with a suitable amine, such as methylamine. The reaction is typically catalyzed by a coupling agent like 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) in the presence of a base like triethylamine.

6-Methyl-1,3-benzodioxol-5-amine finds applications in the pharmaceutical industry as an intermediate in the synthesis of drugs. It is also used in the polymer industry for the modification of polymer properties and in the sensor industry for developing sensitive chemical sensors due to its unique chemical reactivity.

When handling 6-Methyl-1,3-benzodioxol-5-amine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be stored in a closed container in a cool, dry place away from direct sunlight. In case of spill, use a fume hood and follow standard spill procedures. For detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).