N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide(CAS: 101463-69-8)

N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide (CAS: 101463-69-8) is a crystalline solid with a molecular weight of approximately 569.2 g/mol. It has a low solubility in water but is soluble in organic solvents like dimethylformamide (DMF) and dichloromethane. Chemically, it is reactive towards nucleophiles, particularly amino groups, and exhibits good stability under normal storage conditions.

N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide is synthesized via a multi-step process involving the coupling of 2,6-difluorobenzamide with an appropriate amino acid derivative. Commonly, the synthesis involves the use of a coupling reagent such as HATU and a base like diisopropylethylamine. The process yields a high purity product with good selectivity and a yield of around 70-75%.

N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide (CAS: 101463-69-8) is primarily used in the pharmaceutical industry for the development of novel drug candidates. It also finds applications in the synthesis of functional materials and sensors. Its unique chemical structure makes it a valuable intermediate in organic synthesis.

When handling N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide (CAS: 101463-69-8), it is crucial to use appropriate personal protective equipment (PPE) including gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate solvents, and in case of exposure, seek medical attention immediately. Refer to the Safety Data Sheet (SDS) for detailed handling instructions.