1-(3-Pyridinyl)-1-butanone(CAS: 1701-70-8)

1-(3-Pyridinyl)-1-butanone has a crystalline form with a molecular weight of approximately 161.17 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is reactive and can undergo nucleophilic substitution reactions and condensation reactions.

1-(3-Pyridinyl)-1-butanone is typically synthesized via the reaction of 3-pyridylamine with acetone. The reaction involves the formation of an intermediate amide which then undergoes acid-catalyzed hydrolysis to form the ketone. Common catalysts include hydrochloric acid and acetic acid, with yield and selectivity varying depending on the conditions.

1-(3-Pyridinyl)-1-butanone is used in various industries. It is primarily used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry as a monomer, and in the sensor industry for detection applications. It also finds use in the semiconductor industry as a precursor for organic semiconductors.

When handling 1-(3-Pyridinyl)-1-butanone, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation of vapors. Spills should be treated with caution; neutralize with an appropriate chemical and dispose of in accordance with local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.