3-Chloro-2-benzofuran-1(3H)-one(CAS: 6295-21-2)

3-Chloro-2-benzofuran-1(3H)-one is a yellow crystalline solid with a molecular weight of approximately 197.02 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. This compound is moderately reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place to avoid degradation.

3-Chloro-2-benzofuran-1(3H)-one can be synthesized via the condensation of 2-benzofuran-1(3H)-one with thionyl chloride followed by hydrolysis to form the chlorinated product. This reaction is typically performed under anhydrous conditions and in the presence of a catalytic amount of a base like pyridine. The yield is usually around 70-80%, and the selectivity is good for the chlorination reaction.

3-Chloro-2-benzofuran-1(3H)-one is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the polymer industry for the preparation of functional materials and in the sensor industry for the development of gas sensing devices. Additionally, it has potential applications in the semiconductor industry for specific chemical processes.

When handling 3-Chloro-2-benzofuran-1(3H)-one, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, immediately clean up the area and consult the safety data sheet (SDS) for specific instructions. Ensure proper storage in a cool, dry place and avoid contact with incompatible materials like bases or water.