(2,6-Dimethoxyphenyl)boronic acid(CAS: 23112-96-1)

(2,6-Dimethoxyphenyl)boronic acid is a white crystalline solid with a molecular weight of approximately 232.24 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and dichloromethane. The compound exhibits typical reactivity of boronic acids, such as participation in Suzuki-Miyaura cross-coupling reactions. It is stable under normal conditions but should be stored in a cool, dry place away from strong acids and bases.

(2,6-Dimethoxyphenyl)boronic acid is commonly synthesized via the boronation of 2,6-dimethoxybenzene using a boronate ester such as phenylboronic acid as a starting material. The reaction typically involves the use of a base like triphenylphosphine in the presence of a catalyst like palladium(II) acetate. The yield is usually high, and the process is highly selective, making it a reliable method for producing this compound.

(2,6-Dimethoxyphenyl)boronic acid finds applications in various industries, particularly in the pharmaceutical sector for its use as a key intermediate in the synthesis of bioactive compounds. It is also used in the polymer industry for modifying the properties of polymers, in the sensor industry for developing sensitive detection devices, and in semiconductor manufacturing for its role in thin film deposition processes.

When handling (2,6-Dimethoxyphenyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be stored in a fume hood to avoid inhalation risks and to minimize exposure to air. Spills should be cleaned up immediately using appropriate cleanup materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.