(R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol(CAS: 139290-65-6)

The compound (R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol is a white crystalline solid with a molecular weight of approximately 467.4 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. The compound exhibits acidic character and can react with bases. It has low reactivity under normal conditions but can undergo substitution reactions under appropriate conditions.

This compound is typically synthesized via coupling reactions of the appropriate piperidine and 2-(4-fluorophenyl)ethyl derivatives. The synthesis involves the use of a palladium catalyst, such as Pd(PPh3)2Cl2, in the presence of a base like triphenylphosphine. The yield can be around 70-80% with high selectivity to the desired (R)-configuration.

This compound is primarily used in the pharmaceutical industry for the development of new drugs, particularly in the field of central nervous system therapy. It can also be used in the polymer industry as a precursor for functional polymers. Additionally, it may have applications in sensors and semiconductors, although its specific use in these areas is limited.

When handling (R)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be handled using appropriate absorbent materials, and the area should be cleaned thoroughly. Safety data sheets (SDS) should be consulted for detailed handling and disposal instructions.