L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine(CAS: 72122-62-4)

L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine is a crystalline compound with a molecular weight of approximately 815.94 g/mol. It has a low solubility in water and high solubility in organic solvents. The compound is known for its high reactivity, particularly in peptide bond formation. It is stable under neutral and slightly acidic conditions but should be stored away from strong oxidizing agents to prevent degradation.

L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine is synthesized via solid-phase peptide synthesis (SPPS). Commonly, Fmoc (fluorenylmethyloxycarbonyl) or t-Boc (tert-butyloxycarbonyl) protection strategies are used. The synthesis involves coupling of the respective amino acid building blocks using suitable coupling reagents such as HATU (O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) and HOBt (1-hydroxybenzotriazole). The final step involves cleavage from the solid support and deprotection to yield the desired peptide.

L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine is primarily used in the pharmaceutical industry for the development of bioactive peptides and therapeutic molecules. It can also be utilized in polymer synthesis, where its unique sequence can impart specific properties. Additionally, it may find applications in the production of sensors and in semiconductor materials due to its structural complexity.

When handling L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl-L-isoleucine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a cool, dry place away from strong oxidizing agents. Spills should be cleaned up with care, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.