6-Chloro-1H-indole-3-carbonitrile(CAS: 194490-17-0)

6-Chloro-1H-indole-3-carbonitrile has a crystalline form with a molecular weight of 190.04 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound is known for its high reactivity towards nucleophiles and electrophiles. It can undergo electrophilic aromatic substitution and nucleophilic addition reactions.

6-Chloro-1H-indole-3-carbonitrile is typically synthesized via the cyanation of 6-chloro-1H-indole using sodium cyanide in an organic solvent like dimethylformamide (DMF). This process involves the use of a catalyst such as potassium carbonate to enhance the reaction yield. The reaction is usually carried out under nitrogen atmosphere to prevent reaction with oxygen. The yield is typically around 70-80%.

6-Chloro-1H-indole-3-carbonitrile is used in the pharmaceutical industry for the synthesis of various indole derivatives and as an intermediate in the development of new drugs. It is also utilized in the polymer industry for the production of advanced polymers and in the chemical sensing industry for developing gas sensors. Additionally, it is explored in the semiconductor industry for specific applications requiring indole derivatives.

When handling 6-Chloro-1H-indole-3-carbonitrile, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area or under a fume hood to prevent inhalation. Spills should be managed with appropriate safety measures, and the incident should be reported to the safety officer. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage recommendations.