2-(4-Morpholinyl)-5-nitrobenzonitrile(CAS: 78252-11-6)

2-(4-Morpholinyl)-5-nitrobenzonitrile is a crystalline solid with a molecular weight of approximately 246.24 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetonitrile. The compound is known for its chemical stability but can react with reducing agents. It is also hygroscopic and should be stored in a desiccated state.

2-(4-Morpholinyl)-5-nitrobenzonitrile can be synthesized by first reacting 5-nitrobenzonitrile with morpholine in the presence of a suitable base such as potassium carbonate. The reaction is typically performed in an organic solvent like dimethylformamide (DMF) at room temperature. The final product can be isolated by crystallization from appropriate solvents.

2-(4-Morpholinyl)-5-nitrobenzonitrile is primarily used in the pharmaceutical industry as an intermediate for synthesizing various drug molecules. It is also utilized in the polymer industry for the development of advanced materials. Additionally, it finds applications in the sensor and semiconductor industries due to its electronic properties.

When handling 2-(4-Morpholinyl)-5-nitrobenzonitrile, it is essential to wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and a lab coat. The material should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.