1-N-Boc-3-cyanopiperidine(CAS: 91419-53-3)

1-N-Boc-3-cyanopiperidine is a colorless to white crystalline solid. Its molecular weight is approximately 249.3 g/mol. It is slightly soluble in water but soluble in organic solvents like methanol, ethanol, and acetonitrile. The compound is known to be moderately reactive, particularly toward nucleophiles. It can undergo deprotection reactions to form 3-cyanopiperidine under basic conditions.

1-N-Boc-3-cyanopiperidine is typically synthesized from 3-cyanopiperidine and Boc2O ( tert-Butyloxycarbonyl chloride) in the presence of a base such as diisopropylethylamine (DIPEA). The reaction involves the formation of a tert-butyl ester derivative, which is then purified by recrystallization or column chromatography. The yield is usually high, around 85-90%.

1-N-Boc-3-cyanopiperidine is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the chemical industry for the development of polymer monomers and in the sensor industry for the production of gas sensors. Additionally, it has applications in the semiconductor industry for the manufacturing of organic semiconductors.

When handling 1-N-Boc-3-cyanopiperidine, it is important to use appropriate personal protective equipment (PPE) such as gloves, protective goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using an appropriate solvent, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.