2-Ethyl-4,5-dihydro-1,3-oxazole(CAS: 10431-98-8)

2-Ethyl-4,5-dihydro-1,3-oxazole (CAS: 10431-98-8) is a colorless liquid with a molecular weight of approximately 118.19 g/mol. It has a slight odor and is practically insoluble in water but soluble in organic solvents like ethanol and acetone. It is slightly acidic and can undergo nucleophilic substitution reactions. Its boiling point is around 120°C, and it is highly flammable.

2-Ethyl-4,5-dihydro-1,3-oxazole can be synthesized by the Beckmann rearrangement of ethyl ethoxymethyleneoxime. This process involves heating ethyl ethoxymethyleneoxime in an acidic medium, typically hydrochloric acid, to produce the desired oxazole. The yield is usually around 70-80%, and the reaction is often conducted in a pressure vessel to ensure complete conversion.

2-Ethyl-4,5-dihydro-1,3-oxazole (CAS: 10431-98-8) finds applications in the pharmaceutical industry as a precursor for the synthesis of various bioactive compounds. It is also used in the polymer industry for the preparation of functional polymers, in the sensor industry for gas sensing applications, and in the semiconductor industry as a dopant material.

When handling 2-Ethyl-4,5-dihydro-1,3-oxazole (CAS: 10431-98-8), ensure proper laboratory safety practices. Use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhaling vapors. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, neutralize the spill with an appropriate absorbent and dispose of it according to your facility’s hazardous waste management guidelines. Always refer to the safety data sheet (SDS) for detailed information.