6-Chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazine(CAS: 7197-01-5)

6-Chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazine is a crystalline compound with a molecular weight of approximately 229.01 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. This compound is known for its reactive nature, particularly with nucleophiles, and it displays significant reactivity in electrophilic aromatic substitution reactions.

6-Chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazine is synthesized through the condensation of 3-methyl[1,2,4]triazolo[4,3-b]pyridazine with chlorine. The reaction typically requires the use of a Lewis acid catalyst, such as aluminum chloride, to enhance the reactivity. The yield of the reaction is around 75-80%, and selectivity is high due to the specific reactivity of the compound.

6-Chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazine is used in various industries, particularly in pharmaceuticals, where it serves as an intermediate for synthesizing active pharmaceutical ingredients. It is also utilized in chemical research, specifically in the development of new materials and sensors. In the semiconductor industry, this compound plays a role in creating advanced thin-film materials.

When handling 6-Chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound can be toxic and corrosive, so it should be handled in a fume hood. Spills should be cleaned up with caution, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal guidelines.