N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine(CAS: 181951-92-8)

N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine is a solid crystalline compound with a molecular weight of approximately 399.44 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and DMF. This compound is reactive towards nucleophiles and can undergo esterification reactions. It has a熔点 around 120-125°C and is stable under normal storage conditions.

N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine is synthesized via the amide coupling of Fmoc-protected phenylalanine and tert-butoxycarbonylmethoxy-protected amino group. The reaction is catalyzed by a suitable coupling reagent like HOBt and DCC. The yield is typically around 75-80%, and the product is isolated by column chromatography.

N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine is primarily used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also applied in the polymer industry for the preparation of functional polymers with specific properties. Additionally, it may be utilized in the development of sensors and semiconductors for their unique chemical functionalities.

When handling N-Fmoc-4-(tert-butoxycarbonylmethoxy)-L-phenylalanine, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The substance should be handled in a well-ventilated area or a fume hood. In case of a spill, use appropriate spill cleanup kits and dispose of the waste according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.