1-(beta-L-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione(CAS: 26287-69-4)

1-(beta-L-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione is a white crystalline solid with a molecular weight of approximately 276.23 g/mol. It has a solubility of about 10 mg/mL in water. The compound is moderately reactive, showing some tendency towards hydrolysis in aqueous solutions. It is not volatile and does not sublimate easily.

1-(beta-L-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione is typically synthesized through a multi-step process involving the reaction of L-ribonucleoside with urea in an appropriate solvent. The reaction is catalyzed by a transition metal complex, resulting in a yield of around 75-80%. The product is then purified by recrystallization from an organic solvent.

1-(beta-L-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione finds applications in the pharmaceutical industry, where it serves as a key intermediate in the synthesis of certain nucleoside analogs used in antiviral and anticancer drugs. It is also used in some research and development activities in the polymer and semiconductor industries.

When handling 1-(beta-L-Ribofuranosyl)-2,4(1H,3H)-pyrimidinedione, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The substance should be stored in a well-ventilated area and handled in a fume hood to minimize inhalation risk. In case of a spill, use appropriate absorbents and dispose of the waste according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and environmental disposal information.