(4-Propylphenyl)boronic acid(CAS: 134150-01-9)

(4-Propylphenyl)boronic acid is a crystalline solid with a molecular weight of approximately 219.3 g/mol. It has a low solubility in water but is soluble in organic solvents such as methanol and ethanol. Chemically, it exhibits mild reactivity with nucleophiles and is often used in Suzuki coupling reactions. It has a pKa of around 7.5, indicating it is a weak acid.

(4-Propylphenyl)boronic acid is typically synthesized via the reaction of 4-iodo-phenylboronic acid with sodium n-propoxide in the presence of a palladium catalyst. The reaction yields (4-Propylphenyl)boronic acid with good selectivity and moderate yield, making it a practical method for laboratory synthesis.

(4-Propylphenyl)boronic acid is widely used in pharmaceuticals for its role in organic synthesis, particularly in Suzuki cross-coupling reactions. It also finds applications in the production of polymers and in the development of chemical sensors. Additionally, it is used in semiconductor manufacturing for specific surface functionalization processes.

When handling (4-Propylphenyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The substance should be stored in a cool, dry place, away from direct sunlight and heat sources. In case of spills, they should be cleaned up immediately, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.