2-Amino-3-nitrobenzoic acid(CAS: 606-18-8)

2-Amino-3-nitrobenzoic acid (CAS: 606-18-8) is a crystalline solid with a molecular weight of 210.12 g/mol. It is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. The compound is reactive towards nucleophiles and can undergo substitution reactions. It has a melting point of 228-230°C and a pKa of 4.5.

2-Amino-3-nitrobenzoic acid is typically synthesized by the nitration of 2-amino benzoic acid. The reaction involves the use of concentrated nitric acid and sulfuric acid as the nitrating agent. The product can be purified by recrystallization from water or ethanol. The yield is generally around 70-80%.

2-Amino-3-nitrobenzoic acid (CAS: 606-18-8) is used in various industries. It is a key intermediate in the synthesis of several pharmaceuticals, particularly nonsteroidal anti-inflammatory drugs (NSAIDs). It also finds applications in the production of dyes, pigments, and as a component in some analytical reagents and sensors.

When handling 2-Amino-3-nitrobenzoic acid (CAS: 606-18-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The material should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials and proper disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed safety information.