5-Bromo-8-fluoroquinoline(CAS: 1133115-78-2)

5-Bromo-8-fluoroquinoline is a solid with a crystalline form and a molecular weight of approximately 243.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound is less reactive than its parent compound, quinoline, but can undergo substitution reactions. It is insoluble in common inorganic acids and bases.

5-Bromo-8-fluoroquinoline is typically synthesized by bromination of 8-fluoroquinoline. The reaction is catalyzed by N-chlorosuccinimide (NCS) and usually yields a high purity product. Other methods include the use of bromine in the presence of a phase-transfer catalyst. The reaction is selective and provides good yield.

5-Bromo-8-fluoroquinoline is used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the chemical industry for polymer synthesis and in the electronics sector for the development of sensors and semiconductors.

When handling 5-Bromo-8-fluoroquinoline, it is essential to use personal protective equipment (PPE) such as gloves and safety goggles. It should be stored in a fume hood and away from heat and sources of ignition. In the event of a spill, it should be cleaned up using appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.