Amifostine Trihydrate(CAS: 112901-68-5)

Amifostine trihydrate is a crystalline compound with a molecular weight of approximately 422.52 g/mol. It is slightly soluble in water and has a low reactivity under normal conditions. Amifostine trihydrate has a melting point of about 145°C and is stable under normal laboratory conditions.

Amifostine trihydrate is synthesized through a multi-step process involving the formation of amifostine from ethyl 4-((2-aminoethoxy)methyl)-2,2-dimethyl-1,3-propanediol and its subsequent hydration to form the trihydrate form. The synthesis typically involves esterification, reduction, and dehydration steps, with high yield and selectivity.

Amifostine trihydrate is primarily used in the pharmaceutical industry, particularly in the treatment of radiation-induced side effects in cancer patients. It is also used in the medical field for radioprotective purposes. While it is not commonly used in industries such as polymers, sensors, or semiconductors, its applications are expanding in the pharmaceutical sector.

When handling amifostine trihydrate, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. It should be handled in a well-ventilated area or fume hood to avoid inhalation. In case of a spill, it should be cleaned up carefully with appropriate spill kits. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.