5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-thione(CAS: 479074-06-1)

5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-thione is a crystalline solid with a molecular weight of approximately 339.37 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO and ethanol. The compound is moderately reactive and susceptible to hydrolysis under basic conditions. It exhibits good stability under normal storage conditions but should be kept away from strong acids and oxidizing agents.

5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-thione is typically synthesized via etherification of 3-(2-propyl-1-methyl-5-pyrazol-3-yl-7H-pyrimidin-4-yl)-2-ethoxyphenol with carbon disulfide in the presence of an appropriate base, such as sodium hydride. The reaction is carried out under anhydrous conditions to avoid side reactions. The product is isolated by recrystallization from ethanol, providing a pure crystalline form with high yield and selectivity.

5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-thione is primarily used in the pharmaceutical industry, where it serves as an intermediate in the synthesis of various drugs. It also finds applications in the chemical sensor industry due to its reactivity and stability. Additionally, it is explored for its potential in semiconductor applications and as a research tool in organic chemistry.

When handling 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-thione, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, neutralize the spill with an appropriate base and dispose of it according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency response information.