L-Valylglycyl-L-valyl-L-alanyl-L-prolylglycine(CAS: 92899-39-3)

L-Valylglycyl-L-valyl-L-alanyl-L-prolylglycine is a crystalline compound with a molecular weight of approximately 555.59 g/mol. It is poorly soluble in water but soluble in organic solvents. Chemically, it is relatively stable but can undergo hydrolysis under acidic or basic conditions. It has a pKa of around 7, indicating a neutral to slightly basic nature.

L-Valylglycyl-L-valyl-L-alanyl-L-prolylglycine is synthesized through a multistep peptide synthesis process, utilizing solid-phase peptide synthesis (SPPS) techniques. Commonly, a protected form of each amino acid is used, and the peptide is constructed stepwise. Key reagents include coupling agents like HATU and scavengers such as HOAc. The final product is deprotected and purified via HPLC.

L-Valylglycyl-L-valyl-L-alanyl-L-prolylglycine is primarily used in the pharmaceutical industry due to its biological activity. It is also explored in the development of certain polymers for biomedical applications, as well as in the production of sensors and semiconductors for their unique chemical structure and reactivity.

When handling L-Valylglycyl-L-valyl-L-alanyl-L-prolylglycine, it is essential to wear proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate reagents, and proper disposal methods should be followed. Always refer to the Safety Data Sheet (SDS) for detailed safety information.