(R)-(-)-2-Phenylbutyric acid(CAS: 938-79-4)

(R)-(-)-2-Phenylbutyric acid is a crystalline solid with a molecular weight of approximately 164.24 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly in esterification and amidation reactions. Its physical properties include a melting point of around 162-164°C and a density of about 1.2 g/cm³.

(R)-(-)-2-Phenylbutyric acid can be synthesized through stereoselective reduction of (2S,3R)-2-Phenyl-3-bromobutyric acid using sodium borohydride. The reaction proceeds with high selectivity, yielding the enantiomer (R)-(-)-2-Phenylbutyric acid in good yield. This method is preferred for its simplicity and high enantioselectivity.

(R)-(-)-2-Phenylbutyric acid finds application in various industries, particularly in pharmaceuticals for the development of drugs, and in the synthesis of peptides and proteins. It is also used in the polymer industry for improving the properties of polymers, and in the field of sensors for its sensitivity to specific analytes. Its use in semiconductors is less common but can be employed in certain specialized applications.

When handling (R)-(-)-2-Phenylbutyric acid (CAS: 938-79-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using absorbent materials, and proper waste disposal procedures should be followed. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.