5-Bromo-2,3-dihydro-1-benzofuran(CAS: 66826-78-6)

5-Bromo-2,3-dihydro-1-benzofuran is a yellow crystalline solid with a molecular weight of approximately 221.03 g/mol. It has a solubility of about 0.1 g/100 mL in water. This compound is moderately reactive and susceptible to bromination, making it useful in organic synthesis. It is slightly soluble in common organic solvents like ethanol and acetone.

5-Bromo-2,3-dihydro-1-benzofuran is typically synthesized via bromination of 2,3-dihydro-1-benzofuran using N-bromosuccinimide (NBS) as the brominating agent. The reaction requires heating and is carried out in an inert atmosphere to prevent unwanted side reactions. The yield is generally around 70-80%, with high selectivity towards the brominated product.

5-Bromo-2,3-dihydro-1-benzofuran is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the development of sensors and semiconductors due to its specific chemical properties. The polymer industry may also use it as a monomer or intermediate.

When handling 5-Bromo-2,3-dihydro-1-benzofuran, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using an appropriate absorbent material, and the area should be flushed with water. Always refer to a safety data sheet (SDS) for specific handling instructions and emergency procedures.