6-Fluoronicotinaldehyde(CAS: 677728-92-6)

6-Fluoronicotinaldehyde is a colorless to light yellow liquid with a vapor pressure of 1.2 mm Hg at 25°C. It has a molecular weight of 148.06 g/mol and a solubility in water of 1.45 g/L. This compound is reactive and prone to hydrolysis and reduction under certain conditions.

6-Fluoronicotinaldehyde is typically synthesized through the reaction of 6-fluoronicotinic acid with formaldehyde in the presence of an acid catalyst such as sulfuric acid. The reaction involves the condensation of the acid with formaldehyde followed by dehydration to form the aldehyde.

6-Fluoronicotinaldehyde is used in the pharmaceutical industry for the synthesis of drug intermediates, particularly in the development of anti-inflammatory and anticancer drugs. It is also utilized in the polymer industry for the production of certain polymers, and in the sensor industry for the development of gas sensors.

When handling 6-Fluoronicotinaldehyde, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a fume hood to minimize exposure to vapors. Spills should be handled with caution, and proper spill cleanup procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.