5H-Chromeno[2,3-b]pyridin-5-one(CAS: 6537-46-8)

5H-Chromeno[2,3-b]pyridin-5-one has a crystalline form and a molecular weight of approximately 218.16 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and acetone. This compound exhibits moderate reactivity under basic conditions and is stable under neutral and acidic conditions. It is a potent electrophile in organic synthesis.

5H-Chromeno[2,3-b]pyridin-5-one is typically synthesized through the condensation of 2-chloro-6-hydroxypyridine with chromone in the presence of a base like sodium hydroxide. The reaction is conducted in an aprotic solvent like dimethylformamide (DMF) and yields a product with a high degree of selectivity and good yield.

5H-Chromeno[2,3-b]pyridin-5-one is used in the pharmaceutical industry for the synthesis of bioactive compounds. It is also utilized in the electronics industry for the production of semiconductors and in the sensor industry for developing chemical sensors due to its unique electronic properties.

When handling 5H-Chromeno[2,3-b]pyridin-5-one, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using a suitable absorbent material. It is recommended to consult the safety data sheet (SDS) for detailed handling and emergency procedures.