(2E)-3-(4-Methoxyphenyl)acrylaldehyde(CAS: 24680-50-0)

(2E)-3-(4-Methoxyphenyl)acrylaldehyde is a colorless liquid with a molecular weight of approximately 168.18 g/mol. It has a low boiling point and is slightly soluble in water. This compound is reactive towards nucleophiles and can undergo addition and condensation reactions. It is typically stored in a cool, dark place to preserve its stability.

(2E)-3-(4-Methoxyphenyl)acrylaldehyde can be synthesized via the Wittig reaction starting from 4-methoxyphenyl phosphonium chloride and propionaldehyde. The reaction typically proceeds with high selectivity and yields of up to 85%. Other methods include direct condensation of 4-methoxybenzaldehyde with acryloyl chloride.

(2E)-3-(4-Methoxyphenyl)acrylaldehyde has applications in the pharmaceutical industry for the synthesis of intermediates, in the polymer industry as a monomer, and in the sensor industry for the development of selective gas sensors. It is also used in the semiconductor industry for specific applications in photolithography and as a precursor in organic synthesis.

When handling (2E)-3-(4-Methoxyphenyl)acrylaldehyde, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory clothing. The compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.