N-(4-Bromophenyl)-2,6-dihydroxybenzamide(CAS: 20788-07-2)

N-(4-Bromophenyl)-2,6-dihydroxybenzamide (CAS: 20788-07-2) is a crystalline solid with a molecular weight of approximately 327.03 g/mol. It has a high solubility in polar solvents such as dimethyl sulfoxide (DMSO) and methanol, but is poorly soluble in water. This compound is relatively stable under normal conditions but can undergo hydrolysis in the presence of acid or base. It is not reactive towards common organic reagents but can undergo electrophilic aromatic substitution reactions.

N-(4-Bromophenyl)-2,6-dihydroxybenzamide is typically synthesized via the coupling of 4-bromobenzoic acid with 2,6-dihydroxybenzamide. The reaction is catalyzed by a palladium-based catalyst under aerobic conditions, providing high selectivity and yield. The reaction is performed in the presence of a base such as potassium carbonate and a suitable solvent like dimethylformamide (DMF).

N-(4-Bromophenyl)-2,6-dihydroxybenzamide (CAS: 20788-07-2) is primarily used in the pharmaceutical industry as an intermediate for the synthesis of medicinal compounds. It also finds applications in the polymer industry as a stabilizer. Additionally, this compound can be used in the development of sensors and as a dopant in semiconductor materials.

When handling N-(4-Bromophenyl)-2,6-dihydroxybenzamide (CAS: 20788-07-2), ensure the use of appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up with appropriate solvents, and the area should be well ventilated. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.