5-Chloro-2-pyrazinecarboxylic acid(CAS: 36070-80-1)

5-Chloro-2-pyrazinecarboxylic acid is a crystalline solid with a molecular weight of approximately 184.57 g/mol. It has a solubility of about 60 mg/L in water and is slightly soluble in common organic solvents. This compound is reactive, particularly towards nucleophiles and bases, and can undergo substitution reactions.

5-Chloro-2-pyrazinecarboxylic acid is often synthesized through the chlorination of 2-pyrazinecarboxylic acid. This process involves the reaction of 2-pyrazinecarboxylic acid with thionyl chloride in the presence of a base like pyridine. The yield is typically high, and the method is well-established in the literature.

5-Chloro-2-pyrazinecarboxylic acid finds applications in various industries. It is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. Additionally, it is utilized in the manufacture of sensors and semiconductors due to its chemical stability and reactivity.

When handling 5-Chloro-2-pyrazinecarboxylic acid, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, it is recommended to use appropriate absorbents and consult the Safety Data Sheet (SDS) for further guidance.