N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide(CAS: 145701-21-9)

N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide is a crystalline solid with a molecular weight of approximately 427.92 g/mol. It has a low solubility in water but good solubility in organic solvents such as acetonitrile. The compound shows moderate reactivity, particularly towards nucleophiles. It is stable under normal laboratory conditions but should be handled under appropriate fume hood conditions to avoid inhalation exposure.

N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide is typically synthesized through a multi-step process involving the synthesis of the 2,6-dichlorophenyl group, followed by a coupling reaction with 5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide. The synthesis can be achieved using a palladium-catalyzed coupling reaction with a suitable base, such as potassium tert-butoxide. The overall yield of the desired product is around 70-80%, with high selectivity towards the target compound.

N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide is used primarily in the pharmaceutical industry as an intermediate for the synthesis of active pharmaceutical ingredients. It is also utilized in research for its potential applications in medicinal chemistry and drug discovery.

When handling N-(2,6-Dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of spillage, immediately clean up the spill using appropriate absorbent materials and dispose of them according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.