3,3-Difluoropyrrolidine hydrochloride (1:1)(CAS: 163457-23-6)

3,3-Difluoropyrrolidine hydrochloride (CAS: 163457-23-6) is a white crystalline solid with a molecular weight of approximately 171.01 g/mol. It has a pKa of 1.9 and is highly soluble in water and organic solvents. This compound exhibits basic properties due to the presence of the hydrochloride salt. It is a versatile precursor in medicinal chemistry and organic synthesis due to its reactivity towards nucleophiles and electrophiles.

3,3-Difluoropyrrolidine hydrochloride can be synthesized via the reaction of 3,3-difluoro-1,2-dihydro-2-oxopyrrole with hydrochloric acid. This process involves the formation of the salt, followed by recrystallization to obtain the desired product. The reaction is typically carried out in aqueous conditions, and the yield is around 70-80%. Catalysts and other reagents may be used to improve selectivity and yield.

3,3-Difluoropyrrolidine hydrochloride (CAS: 163457-23-6) is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various drugs and is also utilized in the preparation of polymers, sensors, and semiconductor materials. Its reactivity and versatility make it a valuable compound in organic synthesis and medicinal chemistry.

When handling 3,3-Difluoropyrrolidine hydrochloride (CAS: 163457-23-6), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to fumes. Spills should be handled with caution, using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures. Proper storage in a cool, dry place away from direct sunlight is recommended to maintain the compound's stability.