(2-Methoxy-5-pyrimidinyl)boronic acid(CAS: 628692-15-9)

(2-Methoxy-5-pyrimidinyl)boronic acid is a white or off-white crystalline solid with a molecular weight of approximately 213.14 g/mol. It is slightly soluble in water and ethanol. This compound is known for its reactivity in organoboron coupling reactions and is typically stable under normal storage conditions. Its physical properties make it suitable for use in organic synthesis and pharmaceutical applications.

(2-Methoxy-5-pyrimidinyl)boronic acid is commonly synthesized via the reaction of 2-methoxy-5-pyrimidone with triphenylphosphine borate. This process involves the use of a catalyst such as tetrakis(triphenylphosphine)palladium(0) and a base like triethylamine. The reaction is carried out under mild conditions, and the yield can be up to 80%. This synthetic method provides a reliable route to this compound for various applications.

(2-Methoxy-5-pyrimidinyl)boronic acid finds use in the pharmaceutical industry for the synthesis of biologically active compounds. It also plays a role in polymer synthesis and the development of sensors. Additionally, this compound is utilized in the semiconductor industry for its electronic properties. Its versatility makes it a valuable intermediate in various chemical processes.

When handling (2-Methoxy-5-pyrimidinyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Keep the compound away from heat sources and ensure proper storage in a cool, dry place. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.