1-(5-Bromo-2-fluorophenyl)ethanone(CAS: 198477-89-3)

1-(5-Bromo-2-fluorophenyl)ethanone (CAS: 198477-89-3) is a white crystalline solid with a molecular weight of 266.04 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and dimethylformamide. This compound is known for its moderate reactivity, especially in nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from moisture and heat.

1-(5-Bromo-2-fluorophenyl)ethanone (CAS: 198477-89-3) can be synthesized by reacting 2-fluoro-5-bromophenol with ethyl chloroformate in the presence of an organic base like triethylamine. The reaction is typically carried out in a solvent such as dichloromethane. The yield is moderate, around 70-80%, with good regioselectivity towards the ethanone product.

1-(5-Bromo-2-fluorophenyl)ethanone (CAS: 198477-89-3) is primarily used in the pharmaceutical and chemical industries due to its reactivity and structural complexity. It serves as a valuable intermediate in the synthesis of various organic compounds, particularly those requiring brominated and fluorinated functionalities. In the polymer industry, it can also be used in the development of special functional polymers.

When handling 1-(5-Bromo-2-fluorophenyl)ethanone (CAS: 198477-89-3), safety goggles and gloves should be worn. It should be stored in a well-ventilated area and away from direct sunlight. Fume hoods should be used during operations to minimize exposure. Spills should be cleaned up using absorbent materials, and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.