2-Chloro-3-nitrobenzoic acid(CAS: 3970-35-2)

2-Chloro-3-nitrobenzoic acid is a crystalline solid with a molecular weight of approximately 213.03 g/mol. It has a pKa of around 2.7 and is moderately soluble in water. It is highly reactive, particularly towards nucleophiles, and shows limited solubility in common organic solvents like ethanol and acetone.

2-Chloro-3-nitrobenzoic acid is typically synthesized by the nitration of 2-chlorobenzoic acid followed by nitration. This involves the use of nitric acid and sulfuric acid as reagents, with careful control over temperature and reaction conditions to ensure high selectivity and yield.

2-Chloro-3-nitrobenzoic acid finds applications in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the development of sensors, semiconductors, and in the production of dyes and pigments due to its chemical reactivity and functional groups.

When handling 2-Chloro-3-nitrobenzoic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a fume hood to minimize exposure. In the event of a spill, it should be immediately contained and cleaned up using appropriate methods, and the area should be thoroughly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.