Imidapril Hydrochloride(CAS: 89396-94-1)

Imidapril Hydrochloride is a crystalline compound with a molecular weight of approximately 426.76 g/mol. It is readily soluble in water and has poor solubility in organic solvents. It is slightly basic in nature with pKa values of 3.75. This compound is stable under normal storage conditions but should be protected from moisture and light to prevent degradation.

Imidapril Hydrochloride is synthesized by the condensation of 2-chloro-6-ethyl-1,4-benzenediamine with 2-aminobenzonitrile followed by hydrolysis and hydrochloride formation. The reaction is catalyzed by Lewis acids such as aluminum chloride and proceeds with good selectivity and yield, making it a feasible industrial synthesis route.

Imidapril Hydrochloride is primarily used in the pharmaceutical industry as an active pharmaceutical ingredient in antihypertensive drugs. It is also utilized in the formulation of certain agricultural chemicals and as a research tool in biological and medical studies.

When handling Imidapril Hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or under a fume hood to avoid inhalation of dust and vapors. Spills should be cleaned up using appropriate absorbents and proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.