4-Amino-3,5-dichlorobenzonitrile(CAS: 78473-00-4)

4-Amino-3,5-dichlorobenzonitrile (CAS: 78473-00-4) is a white crystalline solid with a molecular weight of 265.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong bases to form amines. Its reactivity is influenced by the presence of the dichlorophenyl and nitrile groups.

4-Amino-3,5-dichlorobenzonitrile is typically synthesized via the reaction of 3,5-dichlorobenzonitrile with ammonia in the presence of a catalyst such as a Lewis acid. The process involves the nucleophilic substitution of the nitrile group by ammonia, leading to the formation of the amino group. The reaction is carried out at elevated temperatures and under pressure to enhance selectivity and yield.

4-Amino-3,5-dichlorobenzonitrile (CAS: 78473-00-4) is used in various industries including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It is also utilized in the production of polymers, sensors, and semiconductor materials, due to its specific chemical properties and reactivity.

When handling 4-Amino-3,5-dichlorobenzonitrile (CAS: 78473-00-4), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled using appropriate spill response materials, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for specific handling and storage instructions.