8-Methoxy-8-oxooctanoic acid(CAS: 3946-32-5)

8-Methoxy-8-oxooctanoic acid (CAS: 3946-32-5) is a white crystalline solid with a molecular weight of approximately 214.23 g/mol. It has a pKa of about 4.9. This compound is soluble in water and organic solvents like ethanol and acetone. It is not highly reactive under normal conditions but may undergo hydrolysis under acidic or basic conditions. It has a melting point of around 153-155°C and a boiling point of approximately 290°C at 1 mmHg.

8-Methoxy-8-oxooctanoic acid (CAS: 3946-32-5) can be synthesized via the methylation of 8-oxooctanoic acid followed by the esterification of the resulting methyl ester with methanol in the presence of a strong acid catalyst like sulfuric acid. The yield is typically around 80-85%, and the selectivity towards the desired product is high.

8-Methoxy-8-oxooctanoic acid (CAS: 3946-32-5) finds applications in the pharmaceutical industry for its potential use as a precursor in the synthesis of certain drugs. It is also used in the polymer industry for the modification of polymer properties. Additionally, it can be employed in the development of sensors and as a reagent in analytical chemistry.

When handling 8-Methoxy-8-oxooctanoic acid (CAS: 3946-32-5), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure. In case of a spill, ensure proper containment and cleaning using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed safety guidelines.